The Craig Thompson Lab (2024)

Research

Craig B. Thompson, MD

The Thompson laboratory has proposed that the basis of metazoan cell survival is determined by the inability of cells to take up nutrients in a cell-autonomous fashion. This hypothesis was formulated to explain how multicellularity might have arisen during evolution. We believe the lack of a cell-intrinsic mechanism to regulate nutrient uptake provides the first and most fundamental barrier to cell transformation.

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Featured News

In the Lab

More Evidence that Cellular ‘Death by Iron’ Could Be Promising Avenue of Cancer Treatment

Cancers with certain mutations are vulnerable to ferroptosis, a form of iron-dependent cell death.

Research Published in Genes and Development from Craig Thompson Lab

New research from the Craig Thompson Lab offers a closer look at the transcriptional activators, Yap/Taz, and the role they play in cell growth and macropinocytosis.

Finding

Findings from Two Patients Shed New Light on Drug Resistance in AML

A team at MSK has discovered a previously unknown type of resistance to a new leukemia drug.

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Publications Highlights

King, B., Araki, J., Palm, W., & Thompson, C. B. (2020). Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis.Genes & development, 10.1101/gad.340661.120. Advance online publication.

Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., Smith, M., Herrera, P. S., Chang, H. Y., Satpathy, A. T., van den Brink, M., Cross, J. R., & Thompson, C. B. (2020). Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.Nature immunology,21(9), 1022–1033.

Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B. (2020). Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress.The EMBO journal,39(8), e103334.

Li, A. M., Ducker, G. S., Li, Y., Seoane, J. A., Xiao, Y., Melemenidis, S., Zhou, Y., Liu, L., Vanharanta, S., Graves, E. E., Rankin, E. B., Curtis, C., Massagué, J., Rabinowitz, J. D., Thompson, C. B., & Ye, J. (2020). Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.Molecular cancer research : MCR,18(4), 599–611.

Zhu, J., Berisa, M., Schwörer, S., Qin, W., Cross, J. R., & Thompson, C. B. (2019). Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.Cell metabolism,30(5), 865–876.e5.

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People

Craig B. Thompson, MD

Craig Thompson studies molecular signaling pathways that regulate nutrient uptake and the role these pathways play in the regulation of cell growth and survival.
MD, University of Pennsylvania

[emailprotected]: Email Address

Members

Tullia Lindsten, MD, PhD

Laboratory Member

[emailprotected]
646-888-3284 or 3288: Lab Phone

Ruobing Cui

Graduate Student

Tak Shun Fung

Research Fellow

Viktoria Gabor

Lab Administrative Assistant

[emailprotected]
6468883288: Office Phone

Olivia Jones

Research Tech

Dayi Li

Graduate Student

Charles Ng

Research Fellow

Keunwoo Ryu

Postdoctoral fellow

[emailprotected]
646-888-3285: Lab Phone

Elias Tzoc-Pacheco

Research Tech

Raymond DeMatteo

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Lydia Finley

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Andrew Intlekofer

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Gaspare La Rocca, PhD

Research Fellow

[emailprotected]
646-888-3285: Lab Phone

Scott Olejniczak, PhD

Research Fellow

Wilhelm Palm

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Natasha Pavlova

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Megan Radler

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Santosha Vardhana

Postdoctoral Fellow

[emailprotected]
646-888-3285: Office Phone

Sriram Venneti

Senior Research Associate

[emailprotected]

Jiangbin Ye, PhD

Research Fellow

[emailprotected]
646-888-3285: Lab Phone

Ji Zhang, PhD

Research Fellow

[emailprotected]
646-888-3285: Lab Phone

Leeza Menon

Lab Executive Assistant

[emailprotected]

Jaclyn Regan

Lab Executive Assistant

646-888-3288: Office Phone

Chao Lu

Graduate Student

Patrick Ward, MPhil

Graduate Student

Cory Benjamin

Research Technician

Heesun Cheong, PhD

Research Fellow

Justin Cross, PhD

Research Fellow

Jingwen (Zhou) Araki

Senior Research Technician

[emailprotected]
646-888-3285: Lab Phone

Agata (Aggie) Bielska

Postdoctoral fellow

[emailprotected]
646-888-3285: Lab Phone

Xin Cai

Postdoctoral fellow

[emailprotected]
646-888-3285: Lab Phone

Francesco Cimino

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Madeline Hwee

Research Technician

BA, Biology, Bard College

[emailprotected]
646-888-3285: Lab Phone

Rachel Josselsohn

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Bryan King, PhD

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Yeon Ju Kyung

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Victoria Macera

Research Technician

[emailprotected]
646-888-3285: Lab Phone

Juan Manuel Schvartzman

Postdoctoral fellow

[emailprotected]
646-888-3285: Lab Phone

Simon Schwörer

Postdoctoral Fellow

[emailprotected]
646-888-3285: Lab Phone

Lab Alumni

Lab Affiliations

Geoffrey Beene Cancer Research Center
Gerstner Sloan Kettering Graduate School of Biomedical Sciences

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

[emailprotected]
Lab Head Email
646-888-3285
Lab Phone
646-888-3010
Lab Fax

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Craig B. Thompson discloses the following relationships and financial interests:

Agios Pharmaceuticals
Professional Services and Activities
Albert and Mary Lasker Foundation
Professional Services and Activities
Charles River Laboratories
Equity; Fiduciary Role / Position
Economic Club of New York
Fiduciary Role / Position
Elsevier
Intellectual Property Rights

Hakluyt & Company
Professional Services and Activities
Howard Hughes Medical Institute
Professional Services and Activities
Regeneron Pharmaceuticals, Inc.
Equity; Fiduciary Role / Position
University of Michigan
Intellectual Property Rights

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [emailprotected].

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